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$SYRE

Spyre Therapeutics, Inc. Common Stock

XNASHealth CarePharmaceutical Preparations

$103.20-1.10%$1.15Prev $104.35LIVE Full chart Live alerts
No recent price bars, the chart lights up when SYRE starts printing.

Why is SYRE down today? It is at $103.20 (-1.10%), and our scanner flagged it 42 times on unusual volume this month. See the catalyst behind the move, real-time alerts the moment SYRE spikes, and full due diligence on SYRE — key stats, earnings, dilution and insider activity. Free.

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Our scanner flagged $SYRE 42 times in the last 30 days. Create a free account to track $SYRE, build a watchlist, and get instant unusual-volume alerts — plus 5 free premium days, no card needed.

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Key Stats

Price & performance
Price
$103.20
Change today
-1.10%
Previous close
$104.35
52-week range
$14.51 – $108.14
Valuation & dividend
Market cap
$9.20B
Ownership & volume
Shares outstanding
88.2M
SEC · as of 2026-07-28 · 9d
Insider ownership
<1%
DEF 14A · 2026-04-10
Institutional own.
99.07%
Total held
99.1%
Tradeable float
817K
1% of shares · after <1% insiders + 99% institutions
Short interest
12.5M
▼ -8% vs prior · as of 2026-07-15
Days to cover
9.0d
Avg daily volume
968K
Classification
Sector
Health Care
Industry
Pharmaceutical Preparations
Exchange
XNAS
Relative volumevs this time of day
5m
0.1x
15m
0.2x
1h
0.3x
1D
0.0x

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Trading profile⚡ Ultra-low float · 817K shShortableEasy to borrowNo SSRBorrow via Alpaca · SSR from Reg SHO 201
$SYRE is down 1.1% today and has an active shelf on file. See who may be selling into moves →

Dilution watch

Active shelf

Recent share offering + active shelf on file — the company raised capital and can raise more. If $SYRE runs, these filings show who may be positioned to sell new or newly-registered shares into the move.

Sourced from SEC EDGAR filings (last 9 months); terms read straight from the filing text where available. Ongoing = an at-the-market (ATM) program still selling over time or a live shelf, so it can keep diluting; Completed = a one-time priced sale that already finished. A shelf (S-3) stays effective ~3 years. Form type signals dilution capacity, not an exact share count, and we can't confirm how much of a shelf or ATM remains unused. Not investment advice.

$SYRE Sentiment

Bullish
Bearish75Bullish
📰 News: 3 bull · 0 bearToday: -1.1%👥 Community: 0 bull · 0 bear

Blend of news sentiment, today’s move, and community votes. Not investment advice.

$SYRE Activity

News, unusual-volume alerts, AI-trader trades and community chatter — the whole story, newest first.

Alert· 3h ago +1.44%
$SYRE moved +1.44% in 1 min (Level 1) at 8:41 AM ET
at $105.85
Alert· 22h ago -0.1% vs EMA
$SYRE near 200 EMA: -0.09% from 200 EMA at 2:12 PM ET
at $102.75
Alert· 22h ago 4.8× RVOL
SYRE hit 4.849x RVOL at 2:12 PM ET
at $102.75
Alert· 23h ago -0.4% vs EMA
$SYRE near 200 EMA: -0.40% from 200 EMA at 12:44 PM ET
at $102.18
Alert· 23h ago 3.8× RVOL
SYRE hit 3.749x RVOL at 12:44 PM ET
at $102.18
Alert· 1d ago -1.3% vs EMA
$SYRE near 200 EMA: -1.27% from 200 EMA at 11:52 AM ET
at $101.46
Alert· 1d ago 6.5× RVOL
SYRE hit 6.455x RVOL at 11:52 AM ET
at $101.46
Alert· 1d ago +1.88%
$SYRE moved +1.88% in 1 min (Level 1) at 9:43 AM ET
at $104.68
Alert· 1d ago +1.08%
$SYRE moved +1.08% in 1 min (Level 1) at 9:25 AM ET
at $107.15
Alert· 1d ago +5.5% vs EMA
SYRE 200EMA (5m) Trending · 79 bars · L3 · +5.45% above EMA · slope +1.00%
at $104.94
Alert· 1d ago +3.3% vs EMA
SYRE 200EMA (1m) Trending · 253 bars · L5 · +3.31% above EMA · slope +0.62%
at $104.94
Alert· 1d ago +3.3% vs EMA
SYRE 200EMA (1m) Trending · 253 bars · L5 · +3.31% above EMA · slope +0.62%
at $104.94
Alert· 1d ago +3.3% vs EMA
SYRE 200EMA (1m) Trending · 253 bars · L5 · +3.31% above EMA · slope +0.62%
at $104.94
Alert· 1d ago +2.4% vs EMA
SYRE 50EMA (5m) Trending · 81 bars · L3 · +2.39% above EMA · slope +1.95%
at $104.94
Alert· 1d ago +1.2% vs EMA
SYRE 50EMA (1m) Trending · 83 bars · L3 · +1.19% above EMA · slope +0.89%
at $104.94
Alert· 1d ago +1.2% vs EMA
SYRE 50EMA (1m) Trending · 83 bars · L3 · +1.19% above EMA · slope +0.89%
at $104.94
News· SEC EDGAR· 1d ago
Spyre Therapeutics Reports Second Quarter 2026 Financial Results and Provides Corporate Update
News· SEC EDGAR· 1d ago
Spyre Therapeutics, Inc. filed a Quarterly report (10-Q)
Alert· 1d ago +2.3% vs EMA
$SYRE near 200 EMA: +2.30% from 200 EMA at 1:52 PM ET
at $102.03
Alert· 1d ago 32.6× RVOL
SYRE hit 32.611x RVOL at 1:52 PM ET
at $102.03
Alert· 1d ago +1.7% vs EMA
$SYRE near 200 EMA: +1.74% from 200 EMA at 1:36 PM ET
at $101.30
Alert· 1d ago 2.2× RVOL
SYRE hit 2.222x RVOL at 1:36 PM ET
at $101.30
Alert· 2d ago -1.42%
$SYRE moved -1.42% in 1 min (Level 1) at 9:28 AM ET
at $98.32
Alert· 2d ago -1.0% vs EMA
$SYRE near 200 EMA: -0.97% from 200 EMA at 1:42 PM ET
at $95.40
Alert· 2d ago 3.0× RVOL
SYRE hit 2.983x RVOL at 1:42 PM ET
at $95.40
Alert· 2d ago -1.7% vs EMA
$SYRE near 200 EMA: -1.68% from 200 EMA at 1:10 PM ET
at $95.02
Alert· 2d ago 3.0× RVOL
SYRE hit 3.044x RVOL at 1:10 PM ET
at $95.02
News· SEC EDGAR· 52d ago
Spyre Therapeutics, Inc. filed an 8-K: Regulation FD Disclosure, Other Material Event
News· SEC EDGAR· 65d ago
Spyre Therapeutics, Inc. filed an 8-K: Other Material Event
News· GlobeNewswire Inc.· 113d ago Bullish
Spyre Therapeutics Announces Pricing of Upsized $403.0 Million Public Offering of Common Stock
News· Benzinga· 114d ago Neutral
Spyre Therapeutics Announces Proposed Public Offering of its Common Stock
News· GlobeNewswire Inc.· 114d ago Bullish
Spyre Therapeutics Announces Proposed Public Offering of its Common Stock
News· GlobeNewswire Inc.· 115d ago Bullish
Spyre Announces Potential Best-in-Class SPY001 Part A Induction Results from SKYLINE Trial in Moderate-to-Severe Ulcerative Colitis Patients

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SYRE stock FAQ

Why is $SYRE down today?

SYRE is one of today's most active names, trading on unusually heavy volume (live price and day move above). Our scanner has fired 1 unusual-volume and momentum alert on SYRE today.

What is the SYRE stock price today?

SYRE last traded at $103.20, down 1.10% on the day. The price and chart above update live during market hours (4 AM to 8 PM ET).

Where can I see live SYRE alerts?

The SYRE Live Alerts panel on this page streams real-time unusual volume (RVOL), momentum, halt and 200-EMA alerts from our scanner the moment they fire. Our scanner has flagged SYRE 42 times in the last 30 days.

What exchange is SYRE on?

SYRE (Spyre Therapeutics, Inc. Common Stock) trades on XNAS, with a market cap of about $9.20B in the PHARMACEUTICAL PREPARATIONS sector.

Is SYRE good for day trading?

That depends on your strategy and risk. Day traders look for volume, volatility and a clear trend. Use the live chart, RVOL alerts and 200-EMA context on this page to judge SYRE for yourself. This is not investment advice.

Live data from TheDesperateTrader scanner. Not investment advice.